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Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ( CRISPR )- Cas9, transcription activator-like effector nucleases ( TALEN ), meganucleases, and zinc finger nucleases (ZFN). [1]
Siberia ( / saɪˈbɪəriə / sy-BEER-ee-ə; Russian: Сибирь, romanized : Sibir', IPA: [sʲɪˈbʲirʲ] ⓘ) is an extensive geographical region comprising all of North Asia, from the Ural Mountains in the west to the Pacific Ocean in the east. [3] It has formed part of the sovereign territory of Russia and its predecessor states since ...
Sustainability is a social goal for people to co-exist on Earth over a long time. Definitions of this term are disputed and have varied with literature, context, and time. [2] [1] Sustainability usually has three dimensions (or pillars): environmental, economic, and social. [1]
Black Forest Games GmbH is a German video game developer based in Offenburg. The company was founded in July 2012 by a team of 40 staff members, including chief executive officer Andreas Speer, previously employed by Spellbound Entertainment, which filed for insolvency earlier that year. As of August 2017, it is a subsidiary of THQ Nordic. [2]
As of May 2024, there are 17 supermarket chains currently operating in the United Kingdom. The food retail market has been dominated by the 'big four' supermarkets – Tesco, Sainsbury's, Asda and Morrisons – who made up over three quarters of sector market share in 2010. Tesco is the largest retailer in Great Britain, with a market share of ...
0.8–1.5% (2019, using DSM-IV-TR and ICD-10) [2] Attention deficit hyperactivity disorder ( ADHD) is a neurodevelopmental disorder characterised by executive dysfunction occasioning symptoms of inattention, hyperactivity, impulsivity and emotional dysregulation that are excessive and pervasive, impairing in multiple contexts, and otherwise age ...
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