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Cliff jumping is the leaping off a cliff edge, usually into a body of water, as a form of sport. It may be done as part of the sport of coastal exploration [1] or as a standalone activity. Particular variations on cliff jumping may specify the angle of entry into the water or the inclusion or exclusion of human-made platforms or other equipment ...
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Multiple studies using early CRISPR-cas9 agents found that greater than 50% of RNA-guided endonuclease-induced mutations were not occurring on-target. The Cas9 guide RNA (gRNA) recognizes a 20 bp target DNA sequence, which it binds and cleaves to "edit" the DNA sequence. However, target sequence binding can tolerate mismatches up to several ...
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